Sir2019 is the latest product of the Sir family, widely used for the crystal structure solution of small/medium size and proteins single-crystal structures using either X-ray or electron diffraction data.
It includes many new features that are described in the program help. Among them:
Ab initio phasing approaches:
- Modern Direct Methods (MDM)
- Standard Direct Methods (SDM)
- Vive la Difference (VLD)
- Patterson pipeline (from the application of Patterson techniques to automatic model building)
Non ab initio phasing approach
- Simulated Annealing (for s/m molecules)
- A new Molecular Replacement pipeline (from MR application to the automatic model building)
- A SAD/MAD pipeline (from SAD/MAD application to the automatic model building)
Improved integration with Jav, the new visualizer in 3D;
possibilty to start the program using a shelx file (.ins) as input.
Sir2019 supports the main current operating systems.
Windows: Sir2019 runs on Windows 7/8/10; setup packages are provided for these versions of Windows.
Linux: these packages run on the 64 bit versions of the main current distributions.
Mac OS X: Sir2019 is provided for runs on Mac (HighSierra and Mojave).
Source code is provided in tar.gz format.
Reference:
M.C. Burla, R. Caliandro, B. Carrozzini, G. L. Cascarano, C. Cuocci, C. Giacovazzo, M. Mallamo, A. Mazzone and G. Polidori, “Crystal structure determination and refinement via SIR2014”, J. Appl. Cryst. (2015). 48, 306–309